The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

The cellular response to hypoxia is primarily regulated by the hypoxia-inducible factors (HIFs). HIF-1α is also a major mediator of tumor physiology, and its abundance is correlated with therapeutic resistance in a broad range of cancers. Accumulation of HIF-1α under hypoxia is mainly controlled by...

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Detalles Bibliográficos
Autores principales: Koivunen, Peppi, Fell, Stuart M, Lu, Wenyun, Rabinowitz, Joshua D, Kung, Andrew L, Schlisio, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981084/
https://www.ncbi.nlm.nih.gov/pubmed/27525289
http://dx.doi.org/10.2147/HP.S96366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981084/
https://www.ncbi.nlm.nih.gov/pubmed/27525289
http://dx.doi.org/10.2147/HP.S96366

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