Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique

The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME) for oral administration to improve its solubility and enhance its bioavailability. Based on a solubility study, pseudoternary phase diagrams, and Box–Behnken design, the oil/water GMME formulation was optimize...

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Detalles Bibliográficos
Autores principales: Li, Haiying, Pan, Tingting, Cui, Ying, Li, Xiaxia, Gao, Jiefang, Yang, Wenzhi, Shen, Shigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981171/
https://www.ncbi.nlm.nih.gov/pubmed/27540291
http://dx.doi.org/10.2147/IJN.S105419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981171/
https://www.ncbi.nlm.nih.gov/pubmed/27540291
http://dx.doi.org/10.2147/IJN.S105419

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