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Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique

The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME) for oral administration to improve its solubility and enhance its bioavailability. Based on a solubility study, pseudoternary phase diagrams, and Box–Behnken design, the oil/water GMME formulation was optimize...

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Detalles Bibliográficos
Autores principales:	Li, Haiying, Pan, Tingting, Cui, Ying, Li, Xiaxia, Gao, Jiefang, Yang, Wenzhi, Shen, Shigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981171/ https://www.ncbi.nlm.nih.gov/pubmed/27540291 http://dx.doi.org/10.2147/IJN.S105419

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