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Medial HOXA genes demarcate haematopoietic stem cell fate during human development

Pluripotent stem cells (PSC) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-renewal of PSC-HSPCs. Using two-step differentiation, human embryonic stem cells (hESCs) differentiated in vitro into...

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Detalles Bibliográficos
Autores principales: Dou, Diana R., Calvanese, Vincenzo, Sierra, Maria I., Nguyen, Andrew T., Minasian, Arazin, Saarikoski, Pamela, Sasidharan, Rajkumar, Ramirez, Christina M., Zack, Jerome A., Crooks, Gay M., Galic, Zoran, Mikkola, Hanna K.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981340/
https://www.ncbi.nlm.nih.gov/pubmed/27183470
http://dx.doi.org/10.1038/ncb3354