Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters

BACKGROUND: Phenylketonuria (PKU) is due to a defective hepatic enzyme, phenylalanine (Phe) hydroxylase. Transport of the precursor amino acids from blood into the brain for serotonin and dopamine synthesis is reported to be inhibited by high blood Phe concentrations. Deficiencies of serotonin and d...

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Detalles Bibliográficos
Autores principales: Yano, Shoji, Moseley, Kathryn, Fu, Xiaowei, Azen, Colleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981358/
https://www.ncbi.nlm.nih.gov/pubmed/27513937
http://dx.doi.org/10.1371/journal.pone.0160892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981358/
https://www.ncbi.nlm.nih.gov/pubmed/27513937
http://dx.doi.org/10.1371/journal.pone.0160892

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