Cargando…

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients

Elevated levels of circulating pro-atherogenic uremic solutes, particularly trimethylamine N-oxide (TMAO), have been implicated in cardiovascular disease development in patients with chronic kidney disease (CKD). TMAO is generated from trimethylamine (TMA) via metabolism by hepatic flavin-containing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robinson-Cohen, Cassianne, Newitt, Richard, Shen, Danny D., Rettie, Allan E., Kestenbaum, Bryan R., Himmelfarb, Jonathan, Yeung, Catherine K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981377/ https://www.ncbi.nlm.nih.gov/pubmed/27513517 http://dx.doi.org/10.1371/journal.pone.0161074

Ejemplares similares

High-Density Lipoprotein Lipidomics and Mortality in CKD
por: Lidgard, Benjamin, et al.
Publicado: (2023)

Soluble ST2 and Galectin-3 and Progression of CKD
por: Alam, Mariam L., et al.
Publicado: (2018)

Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
por: Gao, Chongliang, et al.
Publicado: (2017)

The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
por: Bosworth, Cortney, et al.
Publicado: (2012)

Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
por: Fennema, Diede, et al.
Publicado: (2016)

Vitamin D Metabolic Ratio and Risks of Death and CKD Progression
por: Bansal, Nisha, et al.
Publicado: (2019)

APOL1, Sickle Cell Trait, and CKD in the Jackson Heart Study
por: Young, Bessie A., et al.
Publicado: (2021)

Supervised Exercise Intervention and Overall Activity in CKD
por: Pike, Mindy M., et al.
Publicado: (2020)

Physical activity and metabolic health in chronic kidney disease: a cross-sectional study
por: Bowlby, Wilson, et al.
Publicado: (2016)

APOL1, Acid Load, and CKD Progression
por: Pike, Mindy, et al.
Publicado: (2019)

Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis
por: Chapron, A, et al.
Publicado: (2017)

Revisiting the optical properties of the FMO protein
por: Milder, Maaike T. W., et al.
Publicado: (2010)

Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study
por: Bryant, Tyler S., et al.
Publicado: (2019)

Discovery of the Odderon by TOTEM experiments and the FMO approach
por: Martynov, Evgenij, et al.
Publicado: (2019)

Serum Parathyroid Hormone and 25‐Hydroxyvitamin D Concentrations and Risk of Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis
por: Bansal, Nisha, et al.
Publicado: (2014)

Fluorescence-excitation and Emission Spectroscopy on Single FMO Complexes
por: Löhner, Alexander, et al.
Publicado: (2016)

Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD
por: Al-Obaide, Mohammed A. I., et al.
Publicado: (2017)

Production of drug metabolites by human FMO3 in Escherichia coli
por: Catucci, Gianluca, et al.
Publicado: (2020)

FMO4 shapes immuno‐metabolic reconfiguration in hepatocellular carcinoma
por: Luo, Yan, et al.
Publicado: (2022)

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1
por: Mekonnen, Ephrem, et al.
Publicado: (2017)

Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes
por: Alibrandi, Simona, et al.
Publicado: (2021)

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations
por: Barrea, Luigi, et al.
Publicado: (2021)

Hybrid QM/MM study of FMO complex with polarized protein-specific charge
por: Jia, Xiangyu, et al.
Publicado: (2015)

Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
por: El-Serafi, Ibrahim, et al.
Publicado: (2017)

Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts
por: Gao, Chongliang, et al.
Publicado: (2019)

Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers
por: Tang, Yong-Jun, et al.
Publicado: (2017)

Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny
por: Nicoll, C.R., et al.
Publicado: (2023)

Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer
por: Wu, Lichun, et al.
Publicado: (2023)

Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults
por: Fretts, Amanda M., et al.
Publicado: (2022)

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity
por: Massey, William, et al.
Publicado: (2022)

Plasma Oxalate Concentration and Patients With CKD
por: Oka, Yoshinari, et al.
Publicado: (2021)

Trimethylamine N-oxide in atrial fibrillation progression
por: Büttner, Petra, et al.
Publicado: (2020)

Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents
por: Pike, Mindy M., et al.
Publicado: (2023)

Kidney failure, CKD progression and mortality after nephrectomy
por: Ellis, Robert J., et al.
Publicado: (2022)

Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis
por: Geier, Martina, et al.
Publicado: (2015)

Correction: Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
Publicado: (2017)

Nicotine Dependence is Associated with Functional Variation in FMO3, an Enzyme that Metabolizes Nicotine in the Brain
por: Teitelbaum, Aaron M., et al.
Publicado: (2017)

Exciton Lifetime Distributions and Population Dynamics in the FMO Protein Complex from Prosthecochloris aestuarii
por: Reinot, Tonu, et al.
Publicado: (2021)

Influence of FMO3 and CYP3A4 Polymorphisms on the Pharmacokinetics of Teneligliptin in Humans
por: Park, Jin-Woo, et al.
Publicado: (2021)

Rapid detection of FMO3 single nucleotide polymorphisms using a pyrosequencing method
por: Park, Jin-Woo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h38r3qlgikpfjomnggm37vooqg