The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carcinoma. Expression of the RAD51 G151D variant in hum...

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Detalles Bibliográficos
Autores principales: Marsden, Carolyn G., Jensen, Ryan B., Zagelbaum, Jennifer, Rothenberg, Eli, Morrical, Scott W., Wallace, Susan S., Sweasy, Joann B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981402/
https://www.ncbi.nlm.nih.gov/pubmed/27513445
http://dx.doi.org/10.1371/journal.pgen.1006208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981402/
https://www.ncbi.nlm.nih.gov/pubmed/27513445
http://dx.doi.org/10.1371/journal.pgen.1006208

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