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The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype
The RAD51 protein plays a key role in the homology-directed repair of DNA double-strand breaks and is important for maintaining genome stability. Here we report on a novel human RAD51 variant found in an aggressive and therapy-refractive breast carcinoma. Expression of the RAD51 G151D variant in hum...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981402/ https://www.ncbi.nlm.nih.gov/pubmed/27513445 http://dx.doi.org/10.1371/journal.pgen.1006208 |