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Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease
Parkinson’s disease is characterized by the death of dopaminergic neurons in the substantia nigra. To understand the molecular mechanisms of the disease, an in vitro model is important. In the 1990s, we used the SV40 large T antigen to immortalize dopaminergic neurons derived from Embryonic Day 14 r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981411/ https://www.ncbi.nlm.nih.gov/pubmed/27512998 http://dx.doi.org/10.1371/journal.pone.0160847 |