The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

Data from genetically modified mice suggest that benzodiazepine (BDZ)-site agonists with improved selectivity for α2-subtype GABA(A) receptors (α2GABA(A)R) are potentially useful for the treatment of neuropathic pain. Subtype-selective compounds available for preclinical tests in rodents support thi...

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Detalles Bibliográficos
Autores principales: Ralvenius, William T., Acuña, Mario A., Benke, Dietmar, Matthey, Alain, Daali, Youssef, Rudolph, Uwe, Desmeules, Jules, Zeilhofer, Hanns Ulrich, Besson, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981430/
https://www.ncbi.nlm.nih.gov/pubmed/27392635
http://dx.doi.org/10.1016/j.neuropharm.2016.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981430/
https://www.ncbi.nlm.nih.gov/pubmed/27392635
http://dx.doi.org/10.1016/j.neuropharm.2016.07.004

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