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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

Data from genetically modified mice suggest that benzodiazepine (BDZ)-site agonists with improved selectivity for α2-subtype GABA(A) receptors (α2GABA(A)R) are potentially useful for the treatment of neuropathic pain. Subtype-selective compounds available for preclinical tests in rodents support thi...

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Detalles Bibliográficos
Autores principales:	Ralvenius, William T., Acuña, Mario A., Benke, Dietmar, Matthey, Alain, Daali, Youssef, Rudolph, Uwe, Desmeules, Jules, Zeilhofer, Hanns Ulrich, Besson, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981430/ https://www.ncbi.nlm.nih.gov/pubmed/27392635 http://dx.doi.org/10.1016/j.neuropharm.2016.07.004

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