The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine

Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant effects and difficulty replicating the effect o...

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Detalles Bibliográficos
Autores principales: McKinney, Brett A., Lareau, Caleb, Oberg, Ann L., Kennedy, Richard B., Ovsyannikova, Inna G., Poland, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981436/
https://www.ncbi.nlm.nih.gov/pubmed/27513748
http://dx.doi.org/10.1371/journal.pone.0158016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981436/
https://www.ncbi.nlm.nih.gov/pubmed/27513748
http://dx.doi.org/10.1371/journal.pone.0158016

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