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Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer’s disease
During wakefulness, extracellular levels of metabolites in the brain increase. These include amyloid beta (Aβ), which contributes to the pathogenesis of Alzheimer’s disease (AD). Counterbalancing their accumulation in the brain, sleep facilitates the removal of these metabolites from the extracellul...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981560/ https://www.ncbi.nlm.nih.gov/pubmed/26996255 http://dx.doi.org/10.1016/j.smrv.2016.02.002 |