Cargando…

The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria and a promising target for the development of vaccines and antimicrobial compounds against Staphylococcus aureus. Here we demonstrate that mutations in the conditionally essential ltaS (LTA synthase) gene arise spo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bæk, Kristoffer T., Bowman, Lisa, Millership, Charlotte, Dupont Søgaard, Mia, Kaever, Volkhard, Siljamäki, Pia, Savijoki, Kirsi, Varmanen, Pekka, Nyman, Tuula A., Gründling, Angelika, Frees, Dorte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981727/ https://www.ncbi.nlm.nih.gov/pubmed/27507828 http://dx.doi.org/10.1128/mBio.01228-16

Ejemplares similares

ClpX eats randomly
por: Wells, William A.
Publicado: (2005)

Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
por: Jensen, Camilla, et al.
Publicado: (2019)

The Chaperone ClpX Stimulates Expression of Staphylococcus aureus Protein A by Rot Dependent and Independent Pathways
por: Jelsbak, Lotte, et al.
Publicado: (2010)

The role of ClpX in erythropoietic protoporphyria
por: Whitman, Jared C., et al.
Publicado: (2018)

The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis
por: Jensen, Camilla, et al.
Publicado: (2019)

Growth Mode and Carbon Source Impact the Surfaceome Dynamics of Lactobacillus rhamnosus GG
por: Savijoki, Kirsi, et al.
Publicado: (2019)

A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA
por: Bæk, Kristoffer T., et al.
Publicado: (2021)

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
por: Guo, Chenxi, et al.
Publicado: (2023)

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX
por: Stinson, Benjamin M., et al.
Publicado: (2015)

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding
por: Kardon, Julia R, et al.
Publicado: (2020)

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria
por: Kester, Jemila C., et al.
Publicado: (2021)

The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
por: Leodolter, Julia, et al.
Publicado: (2015)

The Protein Chaperone ClpX Targets Native and Non-native Aggregated Substrates for Remodeling, Disassembly, and Degradation with ClpP
por: LaBreck, Christopher J., et al.
Publicado: (2017)

The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development
por: Wood, Nicholas A., et al.
Publicado: (2020)

Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
Publicado: (2015)

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding
por: Martin, Andreas, et al.
Publicado: (2008)

Mycobacterium tuberculosis ClpX Interacts with FtsZ and Interferes with FtsZ Assembly
por: Dziedzic, Renata, et al.
Publicado: (2010)

Tag-Dependent Substrate Selection of ClpX Underlies Secondary Differentiation of Chlamydia trachomatis
por: Wood, Nicholas A., et al.
Publicado: (2022)

Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus
por: Savijoki, Kirsi, et al.
Publicado: (2020)

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA
por: Key, Jana, et al.
Publicado: (2021)

Gain of Spontaneous clpX Mutations Boosting Motility via Adaption to Environments in Escherichia coli
por: Li, Bingyu, et al.
Publicado: (2021)

Comparative analysis of excretory-secretory antigens of Trichinella spiralis and Trichinella britovi muscle larvae by two-dimensional difference gel electrophoresis and immunoblotting
por: Bien, Justyna, et al.
Publicado: (2012)

Food-Like Growth Conditions Support Production of Active Vitamin B12 by Propionibacterium freudenreichii 2067 without DMBI, the Lower Ligand Base, or Cobalt Supplementation
por: Deptula, Paulina, et al.
Publicado: (2017)

Label-free quantitative proteomics and immunoblotting identifies immunoreactive and other excretory-secretory (E/S) proteins of Anoplocephala perfoliata
por: Hautala, Katja, et al.
Publicado: (2022)

Proteomic analysis of the regulatory networks of ClpX in a model cyanobacterium Synechocystis sp. PCC 6803
por: Zhang, Yumeng, et al.
Publicado: (2022)

The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
por: Thabet, Mohammed A., et al.
Publicado: (2023)

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors
por: Chee Wezen, Xavier, et al.
Publicado: (2022)

Insights to the Assembly of a Functionally Active Leptospiral ClpP1P2 Protease Complex along with Its ATPase Chaperone ClpX
por: Dhara, Anusua, et al.
Publicado: (2019)

Single molecule microscopy reveals diverse actions of substrate sequences that impair ClpX AAA+ ATPase function
por: Wang, Xiao, et al.
Publicado: (2022)

New Insights into the Cyclic Di-adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic Dinucleotide for Acid Stress Resistance in Staphylococcus aureus
por: Bowman, Lisa, et al.
Publicado: (2016)

Cross-talk between Two Nucleotide-signaling Pathways in Staphylococcus aureus
por: Corrigan, Rebecca M., et al.
Publicado: (2015)

A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec
por: Schelin, Jenny, et al.
Publicado: (2020)

Secretome profiling of Propionibacterium freudenreichii reveals highly variable responses even among the closely related strains
por: Frohnmeyer, Esther, et al.
Publicado: (2018)

Growth phase‐associated changes in the proteome and transcriptome of Lactobacillus rhamnosus GG in industrial‐type whey medium
por: Laakso, Kati, et al.
Publicado: (2011)

Location, synthesis and function of glycolipids and polyglycerolphosphate lipoteichoic acid in Gram-positive bacteria of the phylum Firmicutes
por: Reichmann, Nathalie T, et al.
Publicado: (2011)

Identification of a Lipoteichoic Acid Glycosyltransferase Enzyme Reveals that GW-Domain-Containing Proteins Can Be Retained in the Cell Wall of Listeria monocytogenes in the Absence of Lipoteichoic Acid or Its Modifications
por: Percy, Matthew G., et al.
Publicado: (2016)

Two-enzyme systems for glycolipid and polyglycerolphosphate lipoteichoic acid synthesis in Listeria monocytogenes
por: Webb, Alexander J, et al.
Publicado: (2009)

The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
por: Stahlhut, Steen G., et al.
Publicado: (2017)

Enzymatic activities and functional interdependencies of Bacillus subtilis lipoteichoic acid synthesis enzymes
por: Wörmann, Mirka E, et al.
Publicado: (2011)

Discovery of genes required for lipoteichoic acid glycosylation predicts two distinct mechanisms for wall teichoic acid glycosylation
por: Rismondo, Jeanine, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gsdlr2rdjfrsmso9f4v28d8mm3