Globin mRNA reduction for whole-blood transcriptome sequencing

The transcriptome analysis of whole-blood RNA by sequencing holds promise for the identification and tracking of biomarkers; however, the high globin mRNA (gmRNA) content of erythrocytes hampers whole-blood and buffy coat analyses. We introduce a novel gmRNA locking assay (GlobinLock, GL) as a robus...

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Detalles Bibliográficos
Autores principales: Krjutškov, Kaarel, Koel, Mariann, Roost, Anne Mari, Katayama, Shintaro, Einarsdottir, Elisabet, Jouhilahti, Eeva-Mari, Söderhäll, Cilla, Jaakma, Ülle, Plaas, Mario, Vesterlund, Liselotte, Lohi, Hannes, Salumets, Andres, Kere, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981843/
https://www.ncbi.nlm.nih.gov/pubmed/27515369
http://dx.doi.org/10.1038/srep31584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981843/
https://www.ncbi.nlm.nih.gov/pubmed/27515369
http://dx.doi.org/10.1038/srep31584

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