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Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

Proteinaceous cytoplasmic inclusions are an indicator of dysfunction in normal cellular proteostasis and a hallmark of many neurodegenerative diseases. We describe a simple and rapid new flow cytometry-based method to enumerate, characterise and, if desired, physically recover protein inclusions fro...

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Detalles Bibliográficos
Autores principales: Whiten, D. R., San Gil, R., McAlary, L., Yerbury, J. J., Ecroyd, H., Wilson, M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981889/
https://www.ncbi.nlm.nih.gov/pubmed/27516358
http://dx.doi.org/10.1038/srep31138