Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity

Although epigenetic abnormalities have been described in Huntington’s disease (HD), the causal epigenetic mechanisms driving neurodegeneration in HD cortex and striatum remain undefined. Using an epigenetic pathway-targeted drug screen, we report that inhibitors of DNA methyltransferases (DNMTs), de...

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Detalles Bibliográficos
Autores principales: Pan, Yanchun, Daito, Takuji, Sasaki, Yo, Chung, Yong Hee, Xing, Xiaoyun, Pondugula, Santhi, Swamidass, S. Joshua, Wang, Ting, Kim, Albert H., Yano, Hiroko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981892/
https://www.ncbi.nlm.nih.gov/pubmed/27516062
http://dx.doi.org/10.1038/srep31022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981892/
https://www.ncbi.nlm.nih.gov/pubmed/27516062
http://dx.doi.org/10.1038/srep31022

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