Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8‐demethyl‐8‐amino‐d‐riboflavin to the antibiotic roseoflavin

N,N‐8‐demethyl‐8‐amino‐d‐riboflavin dimethyltransferase (RosA) catalyses the final dimethylation of 8‐demethyl‐8‐amino‐d‐riboflavin (AF) to the antibiotic roseoflavin (RoF) in Streptomyces davawensis. In the present study, we solved the X‐ray structure of RosA, and determined the binding properties...

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Detalles Bibliográficos
Autores principales: Tongsook, Chanakan, Uhl, Michael K., Jankowitsch, Frank, Mack, Matthias, Gruber, Karl, Macheroux, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982073/
https://www.ncbi.nlm.nih.gov/pubmed/26913589
http://dx.doi.org/10.1111/febs.13690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982073/
https://www.ncbi.nlm.nih.gov/pubmed/26913589
http://dx.doi.org/10.1111/febs.13690

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