Cargando…

Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality

Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (LPS) from different bacteria can be used to independently or mutually activate Jun N-terminal kinase (JNK)/AP1- or NF-κB-driven inflammatory pathways that lead to PTL. Previous studies using Salmonell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pirianov, Grisha, MacIntyre, David A, Lee, Yun, Waddington, Simon N, Terzidou, Vasso, Mehmet, Huseyin, Bennett, Phillip R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982111/ https://www.ncbi.nlm.nih.gov/pubmed/26183892 http://dx.doi.org/10.1530/REP-15-0258

Ejemplares similares

Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes
por: Lim, Sheri, et al.
Publicado: (2012)

Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response
por: Chan, Denise, et al.
Publicado: (2022)

The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
por: Sykes, Lynne, et al.
Publicado: (2012)

Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage
por: Kindinger, Lindsay M., et al.
Publicado: (2016)

First Trimester Circulating MicroRNA Biomarkers Predictive of Subsequent Preterm Delivery and Cervical Shortening
por: Cook, Joanna, et al.
Publicado: (2019)

Whole Blood Holding Time Prior to Plasma Processing Alters microRNA Expression Profile
por: Kim, Sung Hye, et al.
Publicado: (2022)

Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin
por: Brown, Richard G., et al.
Publicado: (2018)

Maternal plasma miRNAs as potential biomarkers for detecting risk of small-for-gestational-age births
por: Kim, Sung Hye, et al.
Publicado: (2020)

Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium
por: Riaposova, Lucia, et al.
Publicado: (2023)

Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes
por: Brown, Richard G., et al.
Publicado: (2019)

Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature
por: Semertzidou, Anita, et al.
Publicado: (2023)

The pregnancy microbiome and preterm birth
por: Bayar, Erna, et al.
Publicado: (2020)

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
por: Tian, Xiaodong, et al.
Publicado: (2021)

NFκB and AP-1 Drive Human Myometrial IL8 Expression
por: Khanjani, Shirin, et al.
Publicado: (2012)

Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics
por: Migale, Roberta, et al.
Publicado: (2016)

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
por: Guma, Monica, et al.
Publicado: (2012)

Jun N-terminal kinase signaling makes a face
por: Hursh, Deborah A., et al.
Publicado: (2016)

Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study
por: Cook, Joanna R., et al.
Publicado: (2017)

The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling
por: Palmer, Charys, et al.
Publicado: (2018)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020)

C‐Jun N‐terminal kinase signalling pathway in response to cisplatin
por: Yan, Dong, et al.
Publicado: (2016)

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
por: Biggi, Silvia, et al.
Publicado: (2017)

Inhibitors of c-Jun N-terminal kinases—JuNK no more?
por: Bogoyevitch, Marie A., et al.
Publicado: (2008)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development
por: Han, Sun-Young
Publicado: (2008)

Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
por: Noguchi, Hirofumi
Publicado: (2019)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

Krox-20 inhibits Jun-NH(2)-terminal kinase/c-Jun to control Schwann cell proliferation and death
por: Parkinson, David B., et al.
Publicado: (2004)

Direct on-swab metabolic profiling of vaginal microbiome host interactions during pregnancy and preterm birth
por: Pruski, Pamela, et al.
Publicado: (2021)

15-Deoxy-Delta-12,14-prostaglandin J2 modulates pro-labour and pro-inflammatory responses in human myocytes, vaginal and amnion epithelial cells
por: Rasheed, Zahirrah BM., et al.
Publicado: (2022)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity
por: Muñoz-Alonso, María J., et al.
Publicado: (2013)

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy
por: Klein, SR, et al.
Publicado: (2015)

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
por: Mitomo, S., et al.
Publicado: (2016)

Prospective observational study of vaginal microbiota pre‐ and post‐rescue cervical cerclage
por: Brown, RG, et al.
Publicado: (2019)

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages
por: Palmer, Charys, et al.
Publicado: (2021)

Activation of the c-Jun NH(2)-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun
por: Fung, To Sing, et al.
Publicado: (2017)

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase
por: Marcus, David J., et al.
Publicado: (2015)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration
por: Andjelković, Ana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nmln7us5j6micrc3ciqeqtpvm3