Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators

BACKGROUND: Cyclophosphamide (CPA) can activate immunogenic tumor cell death, which induces immune-based tumor ablation and long-term anti-tumor immunity in a syngeneic C57BL/6 (B6) mouse GL261 glioma model when CPA is given on a 6-day repeating metronomic schedule (CPA/6d). In contrast, we find tha...

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Detalles Bibliográficos
Autores principales: Wu, Junjie, Jordan, Marie, Waxman, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982114/
https://www.ncbi.nlm.nih.gov/pubmed/27515027
http://dx.doi.org/10.1186/s12885-016-2597-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982114/
https://www.ncbi.nlm.nih.gov/pubmed/27515027
http://dx.doi.org/10.1186/s12885-016-2597-2

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