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Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin

BACKGROUND: The heregulin-1ß/HER3-driven pathway is implicated in several epithelial malignancies and its blockade is currently undergoing clinical investigation. Paradoxically, the status and the regulation of this pathway is poorly known in hepatocellular carcinoma (HCC). METHODS: Using 85 HCC obt...

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Detalles Bibliográficos
Autores principales: Buta, Corina, Benabou, Eva, Lequoy, Marie, Régnault, Hélène, Wendum, Dominique, Meratbene, Fatiha, Chettouh, Hamza, Aoudjehane, Lynda, Conti, Filomena, Chrétien, Yves, Scatton, Olivier, Rosmorduc, Olivier, Praz, Françoise, Fartoux, Laetitia, Desbois-Mouthon, Christèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982118/
https://www.ncbi.nlm.nih.gov/pubmed/27514687
http://dx.doi.org/10.1186/s13046-016-0402-3