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DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression

BACKGROUND: The Synapsins (SYN1, SYN2, and SYN3) are important players in the adult brain, given their involvement in synaptic transmission and plasticity, as well as in the developing brain through roles in axon outgrowth and synaptogenesis. We and others previously reported gene expression dysregu...

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Detalles Bibliográficos
Autores principales: Cruceanu, Cristiana, Kutsarova, Elena, Chen, Elizabeth S., Checknita, David R., Nagy, Corina, Lopez, Juan Pablo, Alda, Martin, Rouleau, Guy A., Turecki, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982122/
https://www.ncbi.nlm.nih.gov/pubmed/27515700
http://dx.doi.org/10.1186/s12888-016-0989-0