PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

PIK3CA, which encodes the p110α subunit of PI3K, is frequently mutated and oncogenic in breast cancer. PI3Kα inhibitors are in clinical development and despite promising early clinical activity, intrinsic resistance is frequent among patients. We have previously reported that residual downstream mTO...

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Detalles Bibliográficos
Autores principales: Castel, Pau, Ellis, Haley, Bago, Ruzica, Toska, Eneda, Razavi, Pedram, Carmona, F. Javier, Kannan, Srinivasaraghavan, Verma, Chandra S., Dickler, Maura, Chandarlapaty, Sarat, Brogi, Edi, Alessi, Dario R., Baselga, José, Scaltriti, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982440/
https://www.ncbi.nlm.nih.gov/pubmed/27451907
http://dx.doi.org/10.1016/j.ccell.2016.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982440/
https://www.ncbi.nlm.nih.gov/pubmed/27451907
http://dx.doi.org/10.1016/j.ccell.2016.06.004

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