Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

The auristatin class of microtubule destabilizers are highly potent cytotoxic agents against several cancer cell types when delivered as antibody drug conjugates. Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define th...

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Detalles Bibliográficos
Autores principales: Waight, Andrew B., Bargsten, Katja, Doronina, Svetlana, Steinmetz, Michel O., Sussman, Django, Prota, Andrea E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982639/
https://www.ncbi.nlm.nih.gov/pubmed/27518442
http://dx.doi.org/10.1371/journal.pone.0160890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982639/
https://www.ncbi.nlm.nih.gov/pubmed/27518442
http://dx.doi.org/10.1371/journal.pone.0160890

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