Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis

BACKGROUND: Hydrogen sulfide (H(2)S), produced by the activity of cystathionine-gamma-lyase (CSE), is a key mediator of inflammation in sepsis. The liver sinusoidal endothelial cells (LSECs) are important target and mediator of sepsis. The aim of this study was to investigate the role of CSE-derived...

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Detalles Bibliográficos
Autores principales: Gaddam, Ravinder Reddy, Fraser, Robin, Badiei, Alireza, Chambers, Stephen, Cogger, Victoria C, Le Couteur, David G, Ishii, Isao, Bhatia, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982653/
https://www.ncbi.nlm.nih.gov/pubmed/27518439
http://dx.doi.org/10.1371/journal.pone.0160521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982653/
https://www.ncbi.nlm.nih.gov/pubmed/27518439
http://dx.doi.org/10.1371/journal.pone.0160521

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