Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

The DNA repair protein RAD52 is an emerging therapeutic target of high importance for BRCA-deficient tumors. Depletion of RAD52 is synthetically lethal with defects in tumor suppressors BRCA1, BRCA2 and PALB2. RAD52 also participates in the recovery of the stalled replication forks. Anticipating tha...

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Detalles Bibliográficos
Autores principales: Hengel, Sarah R, Malacaria, Eva, Folly da Silva Constantino, Laura, Bain, Fletcher E, Diaz, Andrea, Koch, Brandon G, Yu, Liping, Wu, Meng, Pichierri, Pietro, Spies, M Ashley, Spies, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982760/
https://www.ncbi.nlm.nih.gov/pubmed/27434671
http://dx.doi.org/10.7554/eLife.14740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982760/
https://www.ncbi.nlm.nih.gov/pubmed/27434671
http://dx.doi.org/10.7554/eLife.14740

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