Intracellular accumulation of Praziquantel in T lymphoblastoid cell lines, CEM (parental) and CEMvbl(P-gp-overexpressing)

BACKGROUND: Praziquantel (PZQ) is an antihelminthic drug whose P-glycoprotein (P-gp) substrate specificity has not been conclusively characterized. We investigated its specificity by comparing its in vitro intracellular accumulation in CEM (parental), and CEMvbl cells which over express P-gp, a drug...

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Detalles Bibliográficos
Autores principales: Kigen, Gabriel, Edwards, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983413/
https://www.ncbi.nlm.nih.gov/pubmed/27522191
http://dx.doi.org/10.1186/s40360-016-0079-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983413/
https://www.ncbi.nlm.nih.gov/pubmed/27522191
http://dx.doi.org/10.1186/s40360-016-0079-4

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