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Calcineurin β protects brain after injury by activating the unfolded protein response

The Ca(2+)-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with a sarco/endoplasmic reticulum Ca(2+)-ATPase inhibitor, thapsigargin, and with...

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Detalles Bibliográficos
Autores principales: Chen, Yanan, Holstein, Deborah M., Aime, Sofia, Bollo, Mariana, Lechleiter, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983525/
https://www.ncbi.nlm.nih.gov/pubmed/27334877
http://dx.doi.org/10.1016/j.nbd.2016.06.011