Pathological conformations involving the amino terminus of tau occur early in Alzheimer’s disease and are differentially detected by monoclonal antibodies

Conformational changes involving the amino terminus of the tau protein are among the earliest alterations associated with tau pathology in Alzheimer’s disease and other tauopathies. This region of tau contains a phosphatase-activating domain (PAD) that is aberrantly exposed in pathological forms of...

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Detalles Bibliográficos
Autores principales: Combs, Benjamin, Hamel, Chelsey, Kanaan, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983528/
https://www.ncbi.nlm.nih.gov/pubmed/27260838
http://dx.doi.org/10.1016/j.nbd.2016.05.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983528/
https://www.ncbi.nlm.nih.gov/pubmed/27260838
http://dx.doi.org/10.1016/j.nbd.2016.05.016

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