Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats

Objectives: The recommended zolpidem starting dose was lowered in females (5 mg vs. 10 mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown. We hypothesized that such differences were caused by known se...

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Detalles Bibliográficos
Autores principales: Peer, Cody J., Strope, Jonathan D., Beedie, Shaunna, Ley, Ariel M., Holly, Alesia, Calis, Karim, Farkas, Ronald, Parepally, Jagan, Men, Angela, Fadiran, Emmanuel O., Scott, Pamela, Jenkins, Marjorie, Theodore, William H., Sissung, Tristan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983555/
https://www.ncbi.nlm.nih.gov/pubmed/27574509
http://dx.doi.org/10.3389/fphar.2016.00260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983555/
https://www.ncbi.nlm.nih.gov/pubmed/27574509
http://dx.doi.org/10.3389/fphar.2016.00260

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