Targeting cancer using KAT inhibitors to mimic lethal knockouts

Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Imp...

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Detalles Bibliográficos
Autores principales: Brown, James A.L., Bourke, Emer, Eriksson, Leif A., Kerin, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Biochemical Society Focused Meetings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984449/
https://www.ncbi.nlm.nih.gov/pubmed/27528742
http://dx.doi.org/10.1042/BST20160081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984449/
https://www.ncbi.nlm.nih.gov/pubmed/27528742
http://dx.doi.org/10.1042/BST20160081

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