Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair

BACKGROUND: Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) in epithelial ovarian cancer (EOC). The objective of this study was to evaluate the efficacy of the small molecule inhibitor triapine to disrupt HRR and sensitise BRCA wil...

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Detalles Bibliográficos
Autores principales: Ratner, Elena S, Zhu, Yong-Lian, Penketh, Philip G, Berenblum, Julie, Whicker, Margaret E, Huang, Pamela H, Lee, Yashang, Ishiguro, Kimiko, Zhu, Rui, Sartorelli, Alan C, Lin, Z Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984868/
https://www.ncbi.nlm.nih.gov/pubmed/26964031
http://dx.doi.org/10.1038/bjc.2016.54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984868/
https://www.ncbi.nlm.nih.gov/pubmed/26964031
http://dx.doi.org/10.1038/bjc.2016.54

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