Mechanism of phospho-ubiquitin induced PARKIN activation

The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised on the outside of depolarised mitochondria...

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Detalles Bibliográficos
Autores principales: Wauer, Tobias, Simicek, Michal, Schubert, Alexander, Komander, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984986/
https://www.ncbi.nlm.nih.gov/pubmed/26161729
http://dx.doi.org/10.1038/nature14879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984986/
https://www.ncbi.nlm.nih.gov/pubmed/26161729
http://dx.doi.org/10.1038/nature14879

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