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Generation of Functional RNAs from Inactive Oligonucleotide Complexes by Non-enzymatic Primer Extension

[Image: see text] The earliest genomic RNAs had to be short enough for efficient replication, while simultaneously serving as unfolded templates and effective ribozymes. A partial solution to this paradox may lie in the fact that many functional RNAs can self-assemble from multiple fragments. Theref...

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Detalles Bibliográficos
Autores principales: Adamala, Katarzyna, Engelhart, Aaron E., Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984999/
https://www.ncbi.nlm.nih.gov/pubmed/25521912
http://dx.doi.org/10.1021/ja511564d