Transcriptionally regulated and nontoxic delivery of the hyperactive Sleeping Beauty Transposase

The Sleeping Beauty (SB) transposase and, in particular, its hyperactive variant SB100X raises increasing interest for gene therapy application, including genome modification and, more recently, induced pluripotent stem cells (iPS) reprogramming. The documented cytotoxicity of the transposase, when...

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Detalles Bibliográficos
Autores principales: Cocchiarella, Fabienne, Latella, Maria Carmela, Basile, Valentina, Miselli, Francesca, Galla, Melanie, Imbriano, Carol, Recchia, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985251/
https://www.ncbi.nlm.nih.gov/pubmed/27574698
http://dx.doi.org/10.1038/mtm.2016.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985251/
https://www.ncbi.nlm.nih.gov/pubmed/27574698
http://dx.doi.org/10.1038/mtm.2016.38

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