Definition of two agonist types at the mammalian cold-activated channel TRPM8

Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood. Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammali...

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Detalles Bibliográficos
Autores principales: Janssens, Annelies, Gees, Maarten, Toth, Balazs Istvan, Ghosh, Debapriya, Mulier, Marie, Vennekens, Rudi, Vriens, Joris, Talavera, Karel, Voets, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985286/
https://www.ncbi.nlm.nih.gov/pubmed/27449282
http://dx.doi.org/10.7554/eLife.17240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985286/
https://www.ncbi.nlm.nih.gov/pubmed/27449282
http://dx.doi.org/10.7554/eLife.17240

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