Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets

Low bone mass is often associated with elevated bone marrow adiposity. Since osteoblasts and adipocytes are derived from the same mesenchymal stem cell (MSC) progenitor, adipocyte formation may increase at the expense of osteoblast formation. Leptin is an adipocyte-derived hormone known to regulate...

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Detalles Bibliográficos
Autores principales: Lindenmaier, Laurence B., Philbrick, Kenneth A., Branscum, Adam J., Kalra, Satya P., Turner, Russell T., Iwaniec, Urszula T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985531/
https://www.ncbi.nlm.nih.gov/pubmed/27579023
http://dx.doi.org/10.3389/fendo.2016.00110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985531/
https://www.ncbi.nlm.nih.gov/pubmed/27579023
http://dx.doi.org/10.3389/fendo.2016.00110

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