Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure

Background. Endothelial function is impaired in chronic heart failure (CHF). Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function. Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser(1177), dephosphorylation at Thr(495), and...

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Detalles Bibliográficos
Autores principales: Winzer, Ephraim B., Gaida, Pauline, Höllriegel, Robert, Fischer, Tina, Linke, Axel, Schuler, Gerhard, Adams, Volker, Erbs, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985575/
https://www.ncbi.nlm.nih.gov/pubmed/27563480
http://dx.doi.org/10.1155/2016/4826102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985575/
https://www.ncbi.nlm.nih.gov/pubmed/27563480
http://dx.doi.org/10.1155/2016/4826102

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