MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer

Developing new anticancer agents against ovarian cancer is an urgent medical need. MPT0G066, a novel synthetic arylsulfonamide compound, was shown to inhibit cell growth and decrease viability in human ovarian cancer cells. MPT0G066 induced arrest of the cell cycle at the multipolyploidy (MP) phase...

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Detalles Bibliográficos
Autores principales: Huang, Han-Li, Chao, Min-Wu, Li, Ya-Chi, Chang, Li-Hsun, Chen, Chun-Han, Chen, Mei-Chuan, Cheng, Chun-Chun, Liou, Jing-Ping, Teng, Che-Ming, Pan, Shiow-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985652/
https://www.ncbi.nlm.nih.gov/pubmed/27526962
http://dx.doi.org/10.1038/srep31664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985652/
https://www.ncbi.nlm.nih.gov/pubmed/27526962
http://dx.doi.org/10.1038/srep31664

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