Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor (INSR) exists as two isoforms, INSR-A and INSR-B, which results from...

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Detalles Bibliográficos
Autores principales: Malakar, Pushkar, Chartarifsky, Lital, Hija, Ayat, Leibowitz, Gil, Glaser, Benjamin, Dor, Yuval, Karni, Rotem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985653/
https://www.ncbi.nlm.nih.gov/pubmed/27526875
http://dx.doi.org/10.1038/srep31222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985653/
https://www.ncbi.nlm.nih.gov/pubmed/27526875
http://dx.doi.org/10.1038/srep31222

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