Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance

Wnt signaling molecules are associated with obesity, hyperlipidemia, and type 2 diabetes (T2D). Here, we show that two Wnt proteins, WNT3a and WNT4, are specifically secreted by skeletal muscle and adipose tissue during the development of insulin resistance and play an important role in cross-talk b...

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Detalles Bibliográficos
Autores principales: Kozinski, Kamil, Jazurek, Magdalena, Dobrzyn, Pawel, Janikiewicz, Justyna, Kolczynska, Katarzyna, Gajda, Anna, Dobrzyn, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985739/
https://www.ncbi.nlm.nih.gov/pubmed/27527335
http://dx.doi.org/10.1038/srep31553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985739/
https://www.ncbi.nlm.nih.gov/pubmed/27527335
http://dx.doi.org/10.1038/srep31553

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