Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Increasing evidence supports a role for abnormal immune activation and inflammatory responses in Huntington disease (HD). In this study, we evaluated the therapeutic potential of laquinimod (1 and 10 mg/kg), a novel immunomodulatory agent shown to be protective in a number of neuroinflammatory condi...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Miralles, Marta, Hong, Xin, Tan, Liang Juin, Caron, Nicholas S., Huang, Yihui, To, Xuan Vinh, Lin, Rachel Yanping, Franciosi, Sonia, Papapetropoulos, Spyros, Hayardeny, Liat, Hayden, Michael R., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985819/
https://www.ncbi.nlm.nih.gov/pubmed/27528441
http://dx.doi.org/10.1038/srep31652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985819/
https://www.ncbi.nlm.nih.gov/pubmed/27528441
http://dx.doi.org/10.1038/srep31652

Ejemplares similares