Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

BACKGROUND: Ovarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby inhibiting cytotoxic lymphocytes. Little, however, is known about the effect of adenosine on myeloid cells. Considering that tumor associated m...

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Detalles Bibliográficos
Autores principales: Montalbán del Barrio, Itsaso, Penski, Cornelia, Schlahsa, Laura, Stein, Roland G., Diessner, Joachim, Wöckel, Achim, Dietl, Johannes, Lutz, Manfred B., Mittelbronn, Michel, Wischhusen, Jörg, Häusler, Sebastian F. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986205/
https://www.ncbi.nlm.nih.gov/pubmed/27532024
http://dx.doi.org/10.1186/s40425-016-0154-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986205/
https://www.ncbi.nlm.nih.gov/pubmed/27532024
http://dx.doi.org/10.1186/s40425-016-0154-9

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