A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms

BACKGROUND: Ataxia telangiectasia mutated (ATM) is a detector of double-strand breaks (DSBs) and a crucial component of the DNA damage response (DDR) along with p53 and NF- κB transcription factors and Wip1 phosphatase. Despite the recent advances in studying the DDR, the mechanisms of cell fate det...

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Detalles Bibliográficos
Autores principales: Jonak, Katarzyna, Kurpas, Monika, Szoltysek, Katarzyna, Janus, Patryk, Abramowicz, Agata, Puszynski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986247/
https://www.ncbi.nlm.nih.gov/pubmed/27526774
http://dx.doi.org/10.1186/s12918-016-0293-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986247/
https://www.ncbi.nlm.nih.gov/pubmed/27526774
http://dx.doi.org/10.1186/s12918-016-0293-0

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