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A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms
BACKGROUND: Ataxia telangiectasia mutated (ATM) is a detector of double-strand breaks (DSBs) and a crucial component of the DNA damage response (DDR) along with p53 and NF- κB transcription factors and Wip1 phosphatase. Despite the recent advances in studying the DDR, the mechanisms of cell fate det...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986247/ https://www.ncbi.nlm.nih.gov/pubmed/27526774 http://dx.doi.org/10.1186/s12918-016-0293-0 |