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Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
The common age-related neurodegeneration of Parkinson's disease can result from dominant causes like increased dosage of vesicle-associated alpha-synuclein (SNCA) or recessive causes like deficiency of mitophagy factor PINK1. Interactions between these triggers and their convergence onto shared...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986551/ https://www.ncbi.nlm.nih.gov/pubmed/25296918 http://dx.doi.org/10.1093/hmg/ddu520 |