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Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression

The common age-related neurodegeneration of Parkinson's disease can result from dominant causes like increased dosage of vesicle-associated alpha-synuclein (SNCA) or recessive causes like deficiency of mitophagy factor PINK1. Interactions between these triggers and their convergence onto shared...

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Detalles Bibliográficos
Autores principales:	Gispert, Suzana, Brehm, Nadine, Weil, Jonas, Seidel, Kay, Rüb, Udo, Kern, Beatrice, Walter, Michael, Roeper, Jochen, Auburger, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986551/ https://www.ncbi.nlm.nih.gov/pubmed/25296918 http://dx.doi.org/10.1093/hmg/ddu520

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