Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival

Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently deregulated in different types of blood cancers in humans...

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Detalles Bibliográficos
Autores principales: Sochalska, M, Ottina, E, Tuzlak, S, Herzog, S, Herold, M, Villunger, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986635/
https://www.ncbi.nlm.nih.gov/pubmed/26450454
http://dx.doi.org/10.1038/cdd.2015.130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986635/
https://www.ncbi.nlm.nih.gov/pubmed/26450454
http://dx.doi.org/10.1038/cdd.2015.130

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