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A general method for rapid and cost-efficient large-scale production of 5′ capped RNA

The eukaryotic mRNA 5′ cap structure is indispensible for pre-mRNA processing, mRNA export, translation initiation, and mRNA stability. Despite this importance, structural and biophysical studies that involve capped RNA are challenging and rare due to the lack of a general method to prepare mRNA in...

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Detalles Bibliográficos
Autores principales: Fuchs, Anna-Lisa, Neu, Ancilla, Sprangers, Remco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986899/
https://www.ncbi.nlm.nih.gov/pubmed/27368341
http://dx.doi.org/10.1261/rna.056614.116