Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors

Plasmodium falciparum plasmepsin V (PfPMV) is an essential aspartic protease required for parasite survival, thus, considered as a potential drug target. This study reports the first detailed structural analysis and molecular dynamics simulation of PfPMV as an apoenzyme and its complexes with the su...

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Detalles Bibliográficos
Autores principales: Bedi, Rajiv K., Patel, Chandan, Mishra, Vandana, Xiao, Huogen, Yada, Rickey Y., Bhaumik, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987639/
https://www.ncbi.nlm.nih.gov/pubmed/27531685
http://dx.doi.org/10.1038/srep31420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987639/
https://www.ncbi.nlm.nih.gov/pubmed/27531685
http://dx.doi.org/10.1038/srep31420

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